منابع مشابه
VE - cadherin trans - interaction
Correspondence to Asrar B. Malik: [email protected]; or Yulia A. Komarova: [email protected] Abbreviations used in this paper: AJ, adherens junction; CMV, cytomegalovirus; cRO, caged Rockout; DN, dominant negative; FRET, Förster resonance energy transfer; GAP, GTPase-activating protein; HMEC, human dermal microvascular endothelial cell; MLCII, myosin-II light chain; NMR, nuclear magnetic resonance...
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Because angiogenesis is a key step in a number of pathologic processes, including tumor growth and atherosclerosis, many research studies have investigated the regulatory signals active at various stages of vascular invasion. The differential activities of the endothelial junction protein vascular endothelial (VE)-cadherin reflect the versatile behavior of endothelial cells between vascular qui...
متن کاملBreaking the VE-cadherin bonds.
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signali...
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The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer between blood vessel and irrigated tissues. This crucial function relies on the dynamic architecture of endothelial cell–cell junctions, and in particular, VE -cadherin-mediated contacts. VE -cadherin indeed chiefly organizes the opening and closing of the endothelial barrier, and is central in permeabil...
متن کاملHow VE-cadherin goes with the flow
Vascular endothelial cells respond to changes in blood fl ow (1). Increased fl ow, for example, causes vasodilation and blood vessel remodeling. Collectively, these responses are critical for both vascular development and the maintenance of adult blood vessels. Moreover, disturbed blood fl ow patterns—at artery branch points, for instance—can activate infl ammatory pathways that may initiate th...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2008
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.107.158014